https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:47712 HLA ‐B*57:01 is an established genetic risk factor for flucloxacillin DILI . To consolidate this finding, identify additional genetic factors, and assess relevance of risk factors for flucloxacillin DILI in relation to DILI due to other penicillins, we performed a genomewide association study involving 197 flucloxacillin DILI cases and 6,835 controls. We imputed single‐nucleotide polymorphism and human leukocyte antigen (HLA) genotypes. HLA ‐B*57:01 was the major risk factor (allelic odds ratio (OR ) = 36.62; P = 2.67 x 10⁻⁹⁷). HLA ‐B*57:03 also showed an association (OR = 79.21; P = 1.2 x 10⁻⁶). Within the HLA ‐B protein sequence, imputation showed valine⁹⁷, common to HLA ‐B*57:01 and HLA ‐B*57:03, had the largest effect (OR = 38.1; P = 9.7 x 10⁻⁹⁷). We found no HLA ‐B*57 association with DILI due to other isoxazolyl penicillins (n = 6) or amoxicillin (n = 15) and no significant non‐HLA signals for any penicillin‐related DILI.]]> Tue 21 Mar 2023 18:39:29 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:48167 Fri 10 Mar 2023 18:24:35 AEDT ]]>